Gout is caused by too much uric acid in the blood that leads to a build-up of uric acid crystals in the joints. These crystals cause the characteristic pain and inflammation of gout. Uric acid is produced by an enzyme in the body called xanthine oxidase. Febuxostat inhibits the action of this enzyme and, as a result, lowers uric acid levels. By lowering uric acid levels in the blood, flare-ups of gout can be prevented.
Brand Manufacturer: Patheon
Side Effects: Like all medicines, using Feburic may cause side effects in some users. The following rare (may affect up to 1 in 1,000 people) side effects occur because a serious allergic reaction might follow: -Anaphylactic reactions, drug hypersensitivity -Skin rashes characterized by formation of blisters and peeling of the skin and inner surfaces of body cavities such as: mouth and genitals, painful ulcers in the mouth and/or genital areas, accompanied by fever, sore throat and fatigue (StevensJohnson Syndrome/Toxic Epidermal Necrolysis), or enlarged lymph nodes, liver enlargement, hepatitis (up to liver failure), raising of the white cells count in the blood (drug reaction with eosinophilia and systemic symptoms-DRESS) (see section 2 “Special warnings regarding the use of this medicine”). -Generalized skin rashes. Refer to your doctor immediately if: You suffer from pain, tenderness or weakness of the muscles. These effects can indicate muscle damage, a condition which on rare occasions can be serious. This condition may cause muscle problems and particularly, if at the same time, you feel unwell or have a high temperature it may be caused by an abnormal muscle breakdown. Additional side effects: The common side effects (may affect up to 1 in 10 people) are: abnormal liver function test results diarrhoea headache rash (including various types of rash, see below “uncommon” and “rare” sections) nausea increase in gout symptoms localised swelling due to retention of fluids in tissues (oedema) Uncommon side effects (may affect up to 1 in 100 people) are: decreased appetite, changes in blood sugar levels (diabetes) of which symptoms may be excessive thirst, increased blood fat levels, weight increase loss of sex drive difficulty in sleeping, sleepiness dizziness, numbness, tingling, reduced or altered sensation (hypoesthesia, hemiparesis or paraesthesia), altered sense of taste, diminished sense of smell (hyposmia) abnormal ECG heart tracing, irregular or rapid heartbeats, feeling your heart beat (palpitation) hot flashes or flushing (such as redness of the face or neck), increased blood pressure cough, shortness of breath, chest discomfort or pain, inflammation of nasal passage and/or throat (upper respiratory tract infection), bronchitis dry mouth, abdominal pain or discomfort or wind, heartburn/indigestion, constipation, more frequent passing of stools, vomiting, stomach discomfort itching, hives, skin inflammation, skin discoloration, small red or purple spots on the skin, small flat red spots on the skin, flat red area on the skin that is covered with small confluent bumps, rash, areas of redness and spots on the skin, other types of skin problems muscle cramps, muscle weakness, pain/ache in muscles/joints, bursitis or arthritis (inflammation of joints usually accompanied by pain, swelling and/or stiffness), pain in extremity, back pain, muscle spasms blood in the urine, abnormal frequent urination, abnormal urine tests (increased level of proteins in the urine), a reduction in the ability of the kidneys to function properly fatigue, chest pain, chest discomfort stones in the gallbladder or in bile ducts (cholelithiasis) increase in blood thyroid stimulating hormone (TSH) levels changes in blood chemistry or amount of blood cells or platelets (abnormal blood test results) kidney stones erectile difficulties Rare side effects (may affect up to 1 in 1,000 people) are: muscle damage, a condition which on rare occasions can be serious. It may cause muscle problems and particularly, if at the same time, you feel unwell or have a high temperature it may be caused by an abnormal muscle breakdown. Contact your doctor immediately if you experience muscle pain, tenderness or weakness severe swelling of the deep layers of the skin, especially around the lips, eyes, genitals, hands, feet or tongue, with possible sudden difficult breathing high fever in combination with measles-like skin rash, enlarged lymph nodes, liver enlargement, hepatitis (up to liver failure), raising of the white blood cells count (leukocytosis, with or without eosinophilia) reddening of the skin (erythema), various types of rash (such as: itchy, with white spots, with blisters, with blisters containing pus, with shedding of the skin, measles-like rash), widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis (Stevens-Johnson Syndrome/Toxic epidermal necrolysis) nervousness feeling thirsty ringing in the ears blurred vision, changes in vision hair loss mouth ulceration inflammation of the pancreas: common symptoms are abdominal pain, nausea and vomiting increased sweating weight decrease, increased appetite, uncontrolled loss of appetite (anorexia) muscle and/or joints stiffness abnormally low blood cell counts (white or red blood cells or platelets) urgent need to urinate changes or decrease in urine amount due to inflammation in the kidneys (tubulointerstitial nephritis) inflammation of the liver (hepatitis) yellowing of the skin (jaundice) liver damage increased level of creatine phosphokinase in blood (an indicator of muscle damage)
Indication: The medicine is intended for the treatment of gout in adults, which is characterized by chronic increase of uric acid in the blood (chronic hyperuricemia) and is accompanied with urate deposition (including formation of crystals and/or gouty arthritis).
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