Prograf

Prograf (generic name: tacrolimus) is prescribed together with other medications to help prevent organ rejection after a kidney, liver, heart, or lung transplant. Prograf works to prevent transplant rejection by suppressing the activity of the cells in the immune system that would normally attack the transplanted tissue. Tacrolimus acts on the white blood cells, blocking the action of a substance called calcineurin that is found in white blood cells (T-lymphocytes.) This action prevents the T-lymphocytes from producing substances called lymphokines which are protein mediators that direct the immune system response by signaling between cells. Caution You should not receive any live vaccines while being treated with tacrolimus.
Avoid exposure to ultraviolet (UV) light and restrict the length of time spent either in natural sunlight or tanning
machines. When outdoors in sunlight, wear protective clothing and use sunscreen with a high sun protection factor (SPF).
Do not eat grapefruit or drink grapefruit juice during treatment with Prograf. Dosage Your healthcare provider will instruct you on how to take the prescribed dose. Do not change the dose or stop taking it without talking to the prescribing healthcare provider. Prograf can be taken with or without food, but it must be taken consistently the same way. Prograf should be taken at the same time each day, and the doses must be at least 12 hours apart. An accidental overdose of Prograf can have serious consequences. If you suspect that this may have occurred, immediately call your healthcare provider or go to the nearest hospital emergency room. Do not open or crush Prograf capsules.